Bioxys

HPSE Polyclonal Antibody

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Catalog number:CAC07770
Name:HPSE Polyclonal Antibody
Size:50 μg
Price:245.00
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Extra details

Other name:Heparanase,Endo-glucoronidase,Heparanase-1,Hpa1,Heparanase 8 kDa subunit,Heparanase 50 k,HPSE,HEP,HPA,HPA1,HPR1,HPSE1,HSE1
Immunogen:Recombinant Human Heparanase protein (263-523AA)
Verified reactivity:Human
Verified applications:ELISA,WB,IHC. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200
Raised in:Rabbit
Clonality:Polyclonal
Protein number:Q9Y251
Gene number:Please refer to GenBank
NCBI number:Please refer to NCBI
Purity:Protein G purified,>95%
Storage recommendation:Aliquot and store at -20°C. Minimize freezing and thawing.
Use before:1 year
Shipping requirements:Blue ice
Estimated production time:3-7 business days
Supplementary information:Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
Notes:For research use only. Not for diagnostic procedures.
Properties:If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Group:Polyclonals and antibodies
About:Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
French translation:anticorps

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