17-AAG for cell activation

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Catalog number:1774-5
Name:17-AAG for cell activation
Size:5 mg
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Description:A semi-synthetic derivative of Geldanamycin (Cat. No. 1564-1,5) that displays greater stability and lower in vivo toxicity compared to Geldanamycin. Binds to Heat shock protein 90 (Hsp90) (EC₅₀ = 7.2 µM) in a manner similar to geldanamycin. Exhibits 100-fold higher affinity for tumor-derived Hsp90 over normal cells. Also inhibits Akt activation and HER2 expression in tumor cells.
Peptide sequence:N/A
CAS number:75747-14-7
Molecular weight:585.69
Other name:Telatinib; 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)geldanamycin; Tanespimycin
Molecular formula:C₃₁H₄₃N₃O₈
Physical appearance:Purple solid
Supplied with:N/A
Is this a salt?:No
Is it cell-permeable?:Yes
Purification:≥98% by HPLC
Reconstitute instructions:DMSO (150 mg/ml) or EtOH (5 mg/ml)
Storage condition:-20°C
Shipping condition:gel pack
Maximum time for storage:24 months
Storage instructions:Protect from air and light
Additional description:For cells, cell lines and tissues in culture till half confluency.

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