Bioxys

3-Deazaneplanocin A for cell activation

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Catalog number:2060-1000
Name:3-Deazaneplanocin A for cell activation
Size:1 mg
Price:338.00
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Extra details

Description:A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.
Peptide sequence:N/A
CAS number:102052-95-9
Molecular weight:262.26
Category:Biochemicals
Other name:DZNep; NSC 617989; 5R-​(4-​amino-​1H-​imidazo[4,​5-​c]pyridin-​1-​yl)-​3-​(hydroxymethyl)-​3-​cyclopentene-​1S,​2R-​diol
Molecular formula:C₁₂H₁₄N₄O₃
Physical appearance:Off-white solid
Supplied with:N/A
Is this a salt?:N/A
Is it cell-permeable?:Yes
Purification:≥98%
Reconstitute instructions:DMSO (20 mg/ml) or EtOH (1 mg/ml)
Storage condition:-20°C
Shipping condition:gel pack
Maximum time for storage:24 months
Storage instructions:Protect from air and light
Additional description:For cells, cell lines and tissues in culture till half confluency.

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