10Z-Hymenialdisine for cell activation

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Catalog number:2212-1000
Name:10Z-Hymenialdisine for cell activation
Size:1 mg
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Description:Isolated from sponge Axinella carteri. A potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC₅₀ = 6nM). Blocks the in vivo phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-β (GSK-3β) and CDK5/p35 in Alzheimer’s disease. Inhibitor of DNA damage checkpoint at G2 phase (IC₅₀ = 6 µM), cyclin-dependent kinases CDK1/cyclin B (IC₅₀ = 22 nM), CDK2/cyclin A (IC₅₀= 70 nM), CDK2/cyclin E (IC₅₀= 40 nM), CDK4/cyclin D1 (IC₅₀ = 600 nM), CDK5/p25 (IC₅₀ = 28 nM), GSK-3β (IC₅₀ = 10 nM), and casein kinase 1 (CK1) (IC₅₀ = 35 nM).
Peptide sequence:N/A
CAS number:82005-12-7
Molecular weight:324.13
Other name:4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one; Hymenialdisine
Molecular formula:C₁₁H₁₀BrN₅O₂
Physical appearance:Yellow oil
Supplied with:N/A
Is this a salt?:No
Is it cell-permeable?:Yes
Purification:≥97% by HPLC
Reconstitute instructions:DMSO (5 mg/ml)
Storage condition:-20°C
Shipping condition:gel pack
Maximum time for storage:24months
Storage instructions:Protect from air and light
Additional description:For cells, cell lines and tissues in culture till half confluency.

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