Bioxys

24(S)-Hydroxycholesterol for cell activation

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About product

Catalog number:2411-1
Name:24(S)-Hydroxycholesterol for cell activation
Size:1 mg
Price:208.00
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Extra details

Description:An important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain. It is an endogenous agonist of the nuclear receptor LXR. It has been shown to induce cell death in neuroblastoma cells, possibly via a necroptosis pathway. 24(S)-Hydroxycholesterol has also been found to be a high affinity ligand for RORα and RORγ (Ki = 25 nM). 24(S)-Hydroxycholesterol levels are elevated in the cerebral spinal fluids of patients with neurogenerative diseases suggesting possible clinical applications. It was also able to reduce Aβ production and increase ER-resident immature amyloid precursor protein (APP) levels in human neuroblastoma SH-Sy5Y cells and CHO cells via inhibition of intracellular amyloid precursor protein trafficking.
Peptide sequence:N/A
CAS number:474-73-7
Molecular weight:402.66
Category:Biochemicals
Other name:Cerebrosterol, Cholest-5-ene-3,24-diol, (24S)-24-Hydroxycholesterol, cholest-5-en-3beta,24S-diol
Molecular formula:C₂₇H₄₆O₂
Physical appearance:White solid
Supplied with:N/A
Is this a salt?:No
Is it cell-permeable?:Yes
Purification:≥99% by HPLC
Reconstitute instructions:DMSO (~10 mg/ml) or EtOH (~10 mg/ml)
Storage condition:-20 ̊C
Shipping condition:gel pack
Maximum time for storage:36 months
Storage instructions:Protect from light and air
Additional description:For cells, cell lines and tissues in culture till half confluency.

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