Bioxys

3-Deazaneplanocin A hydrochloride for cell activation

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About product

Catalog number:2444-250
Name:3-Deazaneplanocin A hydrochloride for cell activation
Size:250 µg
Price:126.00
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Extra details

Description:A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.
Peptide sequence:N/A
CAS number:120964-45-6
Molecular weight:298.73
Category:Biochemicals
Other name:DZNep; NSC 617989; 5R-​(4-​amino-​1H-​imidazo[4,​5-​c]pyridin-​1-​yl)-​3-​(hydroxymethyl)-​3-​cyclopentene-​1S,​2R-​diol hydrochloride
Molecular formula:C₁₂H₁₄N₄O₃. HCl
Physical appearance:White to off-white solid
Supplied with:N/A
Is this a salt?:N/A
Is it cell-permeable?:Yes
Purification:≥98% by HPLC
Reconstitute instructions:H₂O (~5 mg/ml)
Storage condition:-20°C
Shipping condition:gel pack
Maximum time for storage:24 months
Storage instructions:Protect from air and moisture
Additional description:For cells, cell lines and tissues in culture till half confluency.

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