(±)-Gossypol for cell activation

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Catalog number:2579-50
Name:(±)-Gossypol for cell activation
Size:50 mg
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Description:Isolated from cotton seeds. It causes infertility in a variety of cotton pests and spermatogenesis arrest in humans. Gossypol also has antimalarial properties, preventing the growth of P. falciparum at low micromolar concentrations. It inhibits aldose reductase (Ki = 0.5 µM).Gossypol also acts as an anticancer agent, inhibiting cell growth in various cancer cell lines, in part by blocking the anti-apoptotic functions of Bcl-2 and Bcl-xL, again at low micromolar concentrations. Also acts as a non-selective competitive inhibitor of NADH binding to LDH, with K(i) values of 1.9, 1.4, and 4.2 µM for LDH-A4, -B4, and -C4, respectively.
Peptide sequence:N/A
CAS number:303-45-7
Molecular weight:518.55
Other name:(±)-2,2′-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene; NSC 56817; NSC 524336; BL 193; Pogosin
Molecular formula:C₃₀H₃₀O₈
Physical appearance:Yellow solid
Supplied with:N/A
Is this a salt?:No
Is it cell-permeable?:Yes
Reconstitute instructions:DMSO (>10 mg/ml) or EtOH (>10 mg/ml with slight warming)
Storage condition:-20°C
Shipping condition:Gel pack
Maximum time for storage:24 months
Storage instructions:Protect from air and light
Additional description:For cells, cell lines and tissues in culture till half confluency.

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