2-Deoxy-D-Glucose for cell activation

View details of this awesome product

About product

Catalog number:B1048-100
Name:2-Deoxy-D-Glucose for cell activation
Size:100 mg
Go to shop   

Extra details

Description:2-Deoxy-D-Glucose is a glucose analog that has long been known to act as a competitive inhibitor of glucose metabolism. Upon transport into the cells, 2-DG is phosphorylated by hexokinase to 2-DG-P. However, unlike G-6-P, 2-DG-P cannot be further metabolized by phosphohexose isomerase, which converts G-6-P to fructose-6-phosphate . 2-Deoxyglucose-P is trapped and accumulated in the cells, leading to inhibition of glycolysis mainly at the step of phosphorylation of glucose by hexokinase. Inhibition of this rate-limiting step by 2-DG causes a depletion of cellular ATP, leading to blockage of cell cycle progression and cell death in vitro.
Peptide sequence:N/A
CAS number:154-17-6
Molecular weight:164.16
Other name:2-Deoxy-D-arabinohexose, 2-Deoxyglucose
Molecular formula:C₆H₁₂O₅
Physical appearance:White to off-white solid
Supplied with:N/A
Is this a salt?:No
Is it cell-permeable?:Yes
Purification:≥98% GC
Reconstitute instructions:H2O (>15 mg/ml) or DMSO (>15 mg/ml)
Storage condition:+4°C
Shipping condition:gel pack
Maximum time for storage:36 months
Storage instructions:Protect from air and moisture
Additional description:For cells, cell lines and tissues in culture till half confluency.

Other suggested products