MMP 14 (MT1-MMP) catalytic domain (Recombinant Protein)

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Catalog number:30 100 102
Name:MMP 14 (MT1-MMP) catalytic domain (Recombinant Protein)
Size:10 µg/ 50µl
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Extra details

Protein type:Recombinant
Protein subtype:EC
Protein family:Matrix Metalloproteinases, matrixins
Protein description:MMP14 seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.
Research area interests:Diseases associated with MMP14 include Winchester Syndrome and Multicentric Osteolysis, Nodulosis, And Arthropathy. Among its related pathways are Signaling events mediated by focal adhesion kinase and Adhesion
Package form:liquid
Tested applications:Activation of progelatinase A; Degaradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard
Other names:Membrane-Type-1 Matrix Metalloproteinase
Peptide sequence:Y A I Q G L K W Q H N E I T F C I Q N Y T P K V G E Y A T Y E A I R K A F R V W E S A T P L R F R E V P Y A Y I R E G H E K Q A D I M I F F A E G F H G D S T P F D G E G G F L A H A Y F P G P N I G G D T H F D S A E P W T V R N E D L N G N D I F L V A V H E L G H A L G L E H S S D P S A I M A P F Y Q W M D T E N F V L P D D D R R G I Q Q L Y G G E S G
Available target modification:No
Expression system:E.coli
Product Subtype:protein fragment
Active form?:Yes
Contents:50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2
Protein purity:>90%
Molecular weight:20 kDa
UniProt number:P50281
Gene number:4323
Abbreviation:MMP14 (partial)
Full name:matrix metallopeptidase 14 (partial)
Other desciption:The catalytic domain of MT1-MMP is produced by activation of a recombinant soluble proform of MT1-MMP purified from E. coli periplasm.
Purification:Mentioned in the data sheet
PubMed citations:See the data sheet
Warnings:For Research Use only.
Shipping conditions:dry ice
Storage condition:Store at -70°C
Technical datasheet:Contact us to receive the datasheet
Source:Recombinants or rec. proteins

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