MMP 16 (MT3-MMP) catalytic domain (Recombinant Protein)

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Catalog number:30 100 303
Name:MMP 16 (MT3-MMP) catalytic domain (Recombinant Protein)
Size:200 µg/ 1 ml
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Extra details

Protein type:Recombinant
Protein subtype:EC
Protein family:Matrix Metalloproteinases, matrixins
Protein description:MMP16 is a endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
Research area interests:Diseases associated with MMP16 include Osteochondrosis. Among its related pathways are Matrix Metalloproteinases and MicroRNAs in cancer.
Package form:liquid
Tested applications:Activation of progelatinase A; Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard
Other names:Membrane-Type 3- Matrix Metalloproteinase
Peptide sequence:L T G R K W Q H K H I T Y S I K N V T P K V G D P E T R K A I R R A F D V W Q N V T P L T F E E V P Y S E L E N G K R D V D I T I I F A S G F H G D S S P F D G E G G F L A H A Y F P G P G I G G D T H F D S D E P W T L G N P N H D G N D L F L V A V H E L G H A L G L E H S N D P T A I M A P F Y Q Y M E T D N F K L P N D D L Q G I Q K I Y G P P D K I P P P T R P L P T V P P H R
Available target modification:No
Expression system:E.coli
Product Subtype:protein fragment
Active form?:Yes
Contents:50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 1 % glycerin, 0.1 % Triton X-100.
Protein purity:0.8
Molecular weight:23 kDa
UniProt number:P51512
Gene number:4325
Abbreviation:MMP16 (partial)
Full name:matrix metallopeptidase 16 (partial)
Other desciption:The catalytic domain of MT3-MMP is produced by activation of a recombinant soluble proform of MT3-MMP purified from E. coli.
Purification:Mentioned in the data sheet
PubMed citations:See the data sheet
Warnings:For Research Use only.
Shipping conditions:dry ice
Storage condition:Store at -70°C
Technical datasheet:Contact us to receive the datasheet
Source:Recombinants or rec. proteins

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