Bioxys

FGFR2 Antibody

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About product

Catalog number:bs-0675R
Name:FGFR2 Antibody
Size:0.1ml
Price:263.00
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Extra details

Long name:FGFR2 Primary Polyclonal Antibody
Also known as:FGFR2 PAb
Category:Primary Antibodies
Conjugation:Unconjugated
Target Antigen:FGFR2
Specificity:This is a highly specific antibody against FGFR2.
Modification(s):None
Modification site(s):Unmodified antibody
Clonality:Polyclonal antibody
Clone number:Polyclonal antibody
Concentration:1ug per 1ul
Subcellular location:Extracellular
Source:This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FGFR2
Gene ID number:2263
Swiss Prot:P21802
Tested Applications:FCM, IHC-P
Recommended dilutions:FCM(1:20-100), IHC-P(1:100-500)
Cross reactivity:Human, Mouse, Rat
Cross reactive species details:Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the target antigen:Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
Purification method:This antibody was purified via Protein A.
Storage conditions:Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Synonym names:BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; Fibroblast growth factor receptor 2; FGFR-2; Keratinocyte growth factor receptor; FGFR2; KSAM
Properties:If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation:anticorps

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