Bioxys

Rb/p105-Rb(Ser249) Antibody

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About product

Catalog number:bs-3558R
Name:Rb/p105-Rb(Ser249) Antibody
Size:0.1ml
Price:281.00
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Extra details

Long name:Rb/p105-Rb(Ser249) Primary Polyclonal Antibody
Also known as:Rb/p105-Rb(Ser249) PAb
Category:Primary Antibodies
Conjugation:Unconjugated
Target Antigen:Rb/p105-Rb Ser249
Specificity:This is a highly specific antibody against Rb/p105-Rb Ser249.
Modification(s):Phosphorylation
Modification site(s):Ser249
Clonality:Polyclonal antibody
Clone number:Polyclonal antibody
Concentration:1ug per 1ul
Source:KLH conjugated synthetic phosphopeptide derived from human Rb around the phosphorylation site of Ser249
Gene ID number:5925
Tested Applications:WB, IHC-P, IF(IHC-P)
Recommended dilutions:WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Cross reactivity:Human, Mouse, Rat
Cross reactive species details:Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the target antigen:Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
Purification method:This antibody was purified via Protein A.
Storage conditions:Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Synonym names:RB1phospho S249; OSRC; P105 RB; P105RB; PP105; PP110; pRb; RB 1; RB1; RB1 protein; Retinoblastoma 1 including osteosarcoma; Retinoblastoma 1; Retinoblastoma associated protein; Including osteosarcoma; Osteosarcoma; p105-Rb; Rb; RB_HUMAN; Retinoblastoma suspectibility protein; Retinoblastoma-associated protein; Retinoblastoma related osteosarcoma; Retinoblastoma susceptibility gene; Including osteosarcoma.
Properties:If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation:anticorps

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