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Bcl2 (Ser87) Antibody, ALEXA FLUOR 350

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Catalog number:bs-12577R-A350
Name:Bcl2 (Ser87) Antibody, ALEXA FLUOR 350
Size:100ul
Price:350.15
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Extra details

Long name:Bcl2 (Ser87) Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
Also known as:Anti-Bcl2 Ser87 PAb ALEXA FLUOR 350
Category:Conjugated Primary Antibodies
Conjugated with:ALEXA FLUOR® 350
Host Organism:Rabbit (Oryctolagus cuniculus)
Target Antigen:Bcl2 Ser87
Specificity:This is a highly specific antibody against Bcl2 Ser87.
Modification:Phosphorylation
Modification Site:Ser87
Clonality:Polyclonal
Clone:Polyclonal antibody
Concentration:1ug per 1ul
Source:KLH conjugated synthetic phosphopeptide derived from human Bcl2 around the phosphorylation site of Ser87
Gene ID Number:596
Tested applications:IF(IHC-P)
Recommended dilutions:IF(IHC-P)(1:50-200)
Crossreactivity:Human, Mouse, Rat
Cross-reactive species details:Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the antigen:BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants (alpha and beta) produced by alternate splicing, differ in their C-terminal ends. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability. It appears to function in a feedback loop system with caspases. BCL2 inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF1). It can form homodimers, and heterodimers with BAX, BAD, BAK and BclX(L). Heterodimerization with BAX requires intact BH1 and BH2 domains, and is necessary for anti-apoptotic activity. Also interacts with APAF1, RAF1, TP53BP2, BBC3, BCL2L1 and BNIPL.
Purification:Purified by Protein A.
Storage conditions:Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Excitation emission:343nm/442nm
Synonyms:Bcl2 phospho S87; Bcl2 phospho Ser87; p-Bcl2 phospho S87; p-Bcl2 Ser87; Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; B cell lymphoma 2; Bcl 2; Bcl-2; Bcl2; BCL2 protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2; BCL2_HUMAN; Apoptosis regulator Bcl-2.
Properties:For facs or microscopy Alexa 1 conjugate.Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Conjugation:Alexa Fluor,ALEXA FLUOR 350
French translation:anticorps

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