SH2D1A Antibody, ALEXA FLUOR 594

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Catalog number:bs-9873R-A594
Name:SH2D1A Antibody, ALEXA FLUOR 594
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Extra details

Long name:SH2D1A Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
Also known as:Anti-SH2D1A PAb ALEXA FLUOR 594
Category:Conjugated Primary Antibodies
Conjugated with:ALEXA FLUOR® 594
Host Organism:Rabbit (Oryctolagus cuniculus)
Target Antigen:SH2D1A
Specificity:This is a highly specific antibody against SH2D1A.
Modification Site:None
Clone:Polyclonal antibody
Concentration:1ug per 1ul
Source:This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SH2D1A/SAP
Gene ID Number:4068
Tested applications:IF(IHC-P)
Recommended dilutions:IF(IHC-P)(1:50-200)
Crossreactivity:Human, Mouse, Rat
Cross-reactive species details:Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the antigen:SH2D1A, also SH2 domain protein 1A, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, influences signaling pathways involving SLAM molecules at the interface between T and B cells. SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM. SLAM activation mediates expansion of activated T cells during immune responses, induces production of interferon-?and changes the functional profile of subsets of T cells. SH2D1A is a hydrophilic, 128 amino acid protein that is 96% homologous to the mouse protein in both SH2 and tail domains. SH2D1A is present in all major subsets of T cells, including CD4+, CD45RO+, CD45RA+ and CD8+, but not in B cells. SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), CD84, CD229 (LY9) and CD244 (2B4).
Purification:Purified by Protein A.
Storage conditions:Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Excitation emission:590nm/617nm
Synonyms:SH2 domain protein 1A; DSHP; Duncan disease SH2 protein; SAP; Signaling lymphocyte activation molecule associated protein; SLAM associated protein; T cell signal transduction molecule SAP; SH21A_HUMAN.
Properties:For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Conjugation:Alexa Fluor,ALEXA FLUOR® 594
Conjugated:Alexa conjugate 1
French translation:anticorps

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