anti-Phospho-BRCA1 Antibody

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About product

Catalog number:3674-100
Name:anti-Phospho-BRCA1 Antibody
Size:Phospho-BRCA1 Antibody
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Extra details

Target of this antibody::Phospho-BRCA1
Alternative names of antibody target::BRCA1, BRCA pSer 1280, Breast Cancer Gene 1, Breast Cancer 1, Early Onset; Breast-Ovarian Cancer Susceptibility
Background information::BRCA1 is a breast cancer susceptibility gene that was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. Like many other genes involved in familial cancer, BRCA1 appears to encode a tumor suppressor, a protein that acts as a negative regulator of tumor growth.
Antibody host::Rabbit
Clonality of antibody::Polyclonal
Isotype::Rabbit IgG
This antibody reacts with::Human
Immunogene sequence::Phosphorylated synthetic peptide surrounding Serine 1189 of human BRCA1
Concentration of antibody::0.5 mg/ml
Form of antibody::Liquid
Formulation of this antibody::100 µg (0.5 mg/ml) peptide affinity purified rabbit anti-phosphorylated BRCA1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Purification method::Affinity purified
This antibody has been succesfully tested for use in following methods::Western blot
Recommended usage::Western blotting (1-2 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been tested yet. Detect human BRCA1 when phosphorylated at Ser1189.
Storage information::Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions::gel pack
How to handle this antibody::The antibody solution should be gently mixed before use.
Description:This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties:If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation:anticorps

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