Anti- Pan FOXD (Polyclonal), ALEXA Fluor 594

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About product

Catalog number:GENTObs-12193R-A594
Name:Anti- Pan FOXD (Polyclonal), ALEXA Fluor 594
Size:100 microliters
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Extra details

Type:Conjugated Primary Antibody
Conjugated with:ALEXA FLUOR® 594
Host organism:Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide:FOXD
Specificity:This antibody is useful for detecting the total expression level FOXD1, 2, 3 and 4. Pan FOXD
Modification:No modification has been applied to this antibody
Modification site:None
Clonality:Polyclonal Antibody
Clone:Polyclonal Antibodies
Concentration:1ug per 1ul
Subcellular locations:Nucleus
Antigen Source:KLH conjugated synthetic peptide derived from human FOXD1
Gene ID:2297, 2298, 27022, 2306
Swiss Prot:Q16676
Applications with corresponding dilutions:IF(IHC-P)(1:50-200)
Cross reactive species:Human (Homo sapiens), Mouse (Mus musculus)
Cross Reactive Species details:No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
Background information:Transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney. Can neuralize ectodermal cells directly By similarity. Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Probable transcription factor involved in embryogenesis and somatogenesis. FOXD1 is involved in regulating inflammation as well as kidney and retinal development. FOXD1 regulates the activity of NFAT and NFkB. Deficiency of FOXD1 results in multiorgan systemic inflammation, exaggerated Th cell-derived cytokine production, and T cell proliferation in autogolgous MLRs. In kidneys, FOXD1 controls the production of signals required for the normal transition of induced mesenchyme into tubular epithelium and full growth and branching of the collecting system. Deletion of FOXD1 results in renal abnormalities. FOXD2 acts as a modulator of T cell activation.
Purification method:Purified by Protein A.
Storage:Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Excitation emission:590nm/617nm
Synonyms:Forkhead box protein D1; Forkhead-related protein FKHL8; Forkhead-related transcription factor 4; FREAC-4Forkhead box protein D2; Forkhead-related protein FKHL17; Forkhead-related transcription factor 9; FREAC-9; FOXD3; FOXD1Forkhead box protein D4; Forkhead-related protein FKHL9; Forkhead-related transcription factor 5; FREAC-5; HNF3/FH transcription factor genesis.
Also known as:Pan FOXD Polyclonal Antibody
Other name:Anti- Pan FOXD Polyclonal
Advisory:Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
Properties:For facs or microscopy Alexa 1 conjugate.
Conjugation:Alexa Fluor,ALEXA FLUOR® 594
Conjugated:Alexa conjugate 1
Description:This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Antibody for research use.
Group:Polyclonals and antibodies
About:Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

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